Using noninvasive adjusted pulse transit time for tracking beat-to-beat systolic blood pressure during ventricular arrhythmia

Tracking beat-to-beat blood pressure noninvasively during ventricular arrhythmia (VA) is of great importance but rarely reported. The goal of our study was to investigate the potential utility of the adjusted pulse transit time (APTT) to track beat-to-beat femoral systolic blood pressure (SBP) during VA. Patients who underwent radiofrequency ablation for arrhythmias at Fuwai Hospital were enrolled. Electrocardiograms (ECGs), finger photoplethysmograms, and femoral arterial blood pressure were recorded simultaneously during VA. The APTT was calculated as the ratio between the square of the conventional pulse transit time (cPTT) and the RR interval of the ECG waveform. Forty-five patients were enrolled in our study, and 22,849 beats were collected during their VA. The inverse of the APTT showed a good correlation with femoral SBP during VA (r = 0.70 ± 0.18). The APTT-derived SBP demonstrated acceptable accuracy in terms of the mean difference ± standard deviation (-0.01 ± 10.54 mmHg) from the invasive femoral SBP. The area under the receiver operating characteristic (ROC) curve for the ability of the APTT to detect ≥30% decreases in femoral SBP was 0.903 (95% confidential interval, 0.895-0.911). In addition, the APTT performed better than the cPTT and RR interval in the above analysis (all P < 0.05). Therefore, the APTT has acceptable accuracy in tracking beat-to-beat femoral SBP and could detect substantially decreased femoral SBP. These findings indicate that the APTT may be a promising noninvasive surrogate for invasive femoral SBP during VA. A multiparameter model combining APTT and other parameters is needed to further improve the accuracy.