四氯化碳
肝损伤
细胞凋亡
肝保护
药理学
炎症
抗氧化剂
自噬
化学
H&E染色
势垒函数
医学
微生物学
免疫学
生物
生物化学
谷胱甘肽
染色
病理
酶
有机化学
细胞生物学
作者
Zhongyue Ren,Yalan Huo,Qingyu Zhang,Shufang Chen,Huihui Lv,Lingling Peng,Hua Wei,Cuixiang Wan
出处
期刊:Nutrients
[MDPI AG]
日期:2021-12-12
卷期号:13 (12): 4441-4441
被引量:3
摘要
Acute liver injury (ALI) has a high mortality rate of approximately 20-40%, and it is imperative to find complementary and alternative drugs for treating ALI. A carbon tetrachloride (CCl4)-induced ALI mouse model was established to explore whether dietary intervention can alleviate ALI in mice. Intestinal flora, intestinal integrity, biomarkers of hepatic function, systemic inflammation, autophagy, and apoptosis signals were detected through a real-time PCR, hematoxylin-eosin staining, 16S rRNA gene sequencing, and so on. The results showed that Lactiplantibacillus plantarum 1201 had a strongly antioxidant ability, and galactooligosaccharide (GOS) could boost its growth. Based on these findings, the combination of L. plantarum 1201 and GOS, the synbiotic, was applied to prevent CCl4-induced ALI in mice. The current research proved that GOS promoted the intestinal colonization of L. plantarum 1201, and the synbiotic improved the antioxidant capacity of the host, regulated the intestinal flora, repaired the intestinal barrier, inhibited the activation of the MAPK/NF-κB pathway, and then inhibited the apoptosis and autophagy pathways, relieving inflammation and liver oxidation; thereby, the ALI of mice was alleviated. These results suggest that synbiotics may become a new research direction for liver-protecting drugs.
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