壳聚糖
免疫疗法
药物输送
放射治疗
生物相容性材料
医学
生物利用度
化疗
不利影响
癌症
癌症免疫疗法
癌症治疗
免疫系统
纳米技术
生物医学工程
药理学
化学
材料科学
免疫学
外科
内科学
生物化学
作者
Xiaoyan Liang,Min Mu,Rangrang Fan,Bingwen Zou,Gang Guo
标识
DOI:10.1016/j.carbpol.2022.119452
摘要
Immunotherapy is an emerging treatment option for use following traditional cancer treatments (surgical resection, radiotherapy and chemotherapy). Due to the complexity of the tumor environment, a single immunotherapy drug cannot readily reach the target site and frequently causes adverse reactions. Chitosan has been used in this emerging field because of its biodegradable, biocompatible, nonimmunogenic and nontoxic properties. Chitosan has been used as a carrier of immunotherapeutic agents to improve bioavailability, regulate the immune system and enhance antitumor response. The easily modified structure of chitosan allows for the construction of many different delivery vectors for better application in immunotherapy. Here, we review the recent applications of chitosan and its derivatives as delivery vectors in cancer immunotherapy, as well as discuss limitations and clarify current trends and future directions. In conclusion, chitosan has a promising future as a delivery material in immunotherapy.
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