Post-stroke depression (PSD) is one of the complications after stroke, with an incidence of \nabout 31%. There are different opinions on the pathogenesis of PSD, but it is still unclear and \nneeds further study. At present, in addition to clinical research, the establishment and research \nof PSD animal model is an important part of the basic research of PSD. Therefore, it is very \nimportant to establish an effective animal model. In this paper, combined with the current \nsituation at home and abroad, the relevant models are summarized and summarized.