RAR相关孤儿受体γ
生物
转录因子
免疫
细胞分化
获得性免疫系统
白细胞介素23
细胞生物学
白细胞介素17
免疫学
免疫系统
基因
遗传学
FOXP3型
作者
Yuhao Zhao,Zhongshan Liu,Lei Qin,Zhihui Wang,Ou Bai
标识
DOI:10.1016/j.molimm.2021.03.010
摘要
Th17 cells are a lineage of CD4+ T helper cells with Th17-specific transcription factors RORγt and RoRα. Since its discovery in 2005, research on Th17 has been in rapid progress, and increasing cytokines or transcription factors have been uncovered in the activation and differentiation of Th17 cells. Furthermore, growing evidence proves there are two different subsets of Th17 cells, namely non-pathogenic Th17 (non-pTh17) and pathogenic Th17 (pTh17), both of which play important roles in adaptive immunity, especially in host defenses, autoimmune diseases, and cancer. In this review, we summarize and discuss the mechanisms of Th17 cells differentiation, and their roles in immunity and diseases.
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