壳聚糖
甲壳素
生物相容性
抗菌剂
化学
多糖
抗菌活性
细菌
表面改性
两亲性
材料科学
核化学
有机化学
共聚物
聚合物
生物
物理化学
遗传学
作者
Fang Xie,Xiaoen Bian,Yiwen Lu,Tian Xia,Didi Xu,Yanfeng Wang,Jie Cai
标识
DOI:10.1016/j.carbpol.2021.118683
摘要
Microbial colonization of catheter surfaces is responsible for most healthcare-associated infections. Quaternized chitin and chitosan have excellent antimicrobial and biocompatible properties and can be used to provide safe and prolonged protection for biomedical catheters. Herein, we prepared quaternized β-chitin derivative (QC)- and quaternized chitosan derivative (QCS)-based antimicrobial surfaces. The quaternized polysaccharides modified TPU surfaces exhibited hydrophilicity, good biocompatibility. Among these, QCS2-modified TPU exhibited excellent antibacterial properties against Gram-positive and Gram-negative bacteria, and prevented the adherence of bacteria compared with pristine TPU. The antibacterial activity of QCS2-modified surfaces maintained for 8 weeks under the condition of immersion in serum. An in vivo subcutaneous implantation experiment revealed 99.87% reduction of bacteria and reduced expression of inflammation-related factors in the surrounding tissue five days after implantation with QCS2-modified TPU. Therefore, quaternized polysaccharide-modified surfaces have promising potential in preventing medical catheter-associated infections.
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