医学
细胞因子
抗体
癌症免疫疗法
癌症研究
免疫疗法
癌症
免疫学
内科学
作者
Jun Ishihara,Ako Ishihara,Koichi Sasaki,Seung Young Lee,John‐Michael Williford,Mariko Yasui,Hiroyuki Abé,Lambert Potin,Peyman Hosseinchi,Kazuto Fukunaga,Michal M. Raczy,Laura Gray,Aslan Mansurov,Kiyomitsu Katsumata,Masashi Fukayama,Stephen J. Kron,Melody A. Swartz,Jeffrey A. Hubbell
标识
DOI：10.1126/scitranslmed.aau3259
摘要
T cells. In an orthotopic breast cancer model, combination treatment with CPI and IL-2 eradicated tumors in 9 of 13 animals with the CBD-modified drugs, whereas it did so in only 1 of 13 animals with the unmodified drugs. Thus, the A3 domain of VWF can be used to improve safety and efficacy of systemically administered tumor drugs with high translational promise.
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(2025-6-4)
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