微塑料
失调
斑马鱼
生物累积
肠道菌群
生物
毒性
微生物学
化学
生态学
生物化学
基因
有机化学
作者
Ruxia Qiao,Yongfeng Deng,Shenghu Zhang,M Wolosker,Qiande Zhu,Hongqiang Ren,Yan Zhang
出处
期刊:Chemosphere
[Elsevier]
日期:2019-12-01
卷期号:236: 124334-124334
被引量:434
标识
DOI:10.1016/j.chemosphere.2019.07.065
摘要
Different shapes of microplastics are widely detected in the environment and organisms and most of them remain in the gut. However, the influences of shapes on the bioaccumulation and toxicity of microplastics in the gut are largely unknown. Three shapes (bead, fragment, and fiber) of microplastics of comparable size in one dimension were prepared to exposure to zebrafish. The accumulation and toxicities of microplastics in the gut were detected. Shape-dependent accumulation in the gut was observed with the order of fibers (8.0 μg/mg) > fragments (1.7 μg/mg) > beads (0.5 μg/mg). The accumulation of microplastics caused multiple toxic effects in fish intestine, including mucosal damage, and increased permeability, inflammation and metabolism disruption. Based on these toxic effects, microplastic fibers resulted in more severe intestinal toxicity than microplastic fragments and beads did. Furthermore, microplastics also induced gut microbiota dysbiosis and specific bacteria alterations, which will provide novel insights into the potential mechanism of microplastics causing intestinal toxicities in fish. Our results also suggested that shape-depended effects should not be ignored in the health risk assessment of microplastics.
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