三氟甲基化
化学
过渡金属
组合化学
催化作用
三氟甲基
反应条件
功能群
药物化学
有机化学
聚合物
烷基
作者
Liping Wang,Yuecheng Zhang,Fanfan Li,Xinyu Hao,Hongyu Zhang,Jiquan Zhao
标识
DOI:10.1002/adsc.201800863
摘要
Abstract Disclosed herein is a direct C−H trifluoromethylation of quinoxalin‐2(1 H )‐ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3‐trifluoromethylquinoxalin‐2(1 H )‐one derivatives in moderate to excellent yields under transition‐metal‐free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition‐metal‐catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones. magnified image
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