Formulation and Development of Floating Microspheres containing Levodopa and Carbidopa

The main objective of work to develop long acting sustained release floating microballons of levodopa and carbidopa by emulsion-solvent evaporation technique for the treatment of Parkinson's disorder. All current levodopa products are formulated in combination with aromatic amino acid decorboxylase inhibitors such as benserazide to prevent the peripheral metabolism of levodopa. In the present research work was to produce floating microspheres of carbidopa and levodopa to enhance their efficacy by increasing their gastric retention time which is major technique to improve efficacy of narrow absorption window drugs, and its improved bioavailability. The effect of various formulation were evaluated and process variable on the particle size, in vitro floating behavior, percentage yield and in vitro drug release were studies. Further, the microspheres could also be compressed in to tablets, filled in to capsule or formulated in to oral suspension for reconstitution.