Brønsted acid-catalysed regiodivergent phosphorylation of 2-indolylmethanols to synthesize benzylic site or C3-phosphorylated indole derivatives

A Brønsted acid catalyzed highly regiodivergent phosphorylation of 2-indolylmethanols with diarylphosphine oxides has been established, which provides an efficient protocol for accessing benzylic site or C3-phosphorylated indole derivatives with structural diversity.