Treatment and analysis the clinicopathologic patholog of gastrointestinal stromal tumors

Objective To explore the clinical behavior, morphology,immunohistochemical characteristics and treat methods of gastrointestinal stromal tumors(GIST),to improve the clinical diagnostic level of GIST.Methods Retrospective analysis was performed over 36 GIST patients based on clinical data and pathological data between Feb. 1993 and Dec. 2004, followed by an immunohistochemical analysis over the specimens using CD117, CD34, Actin and S-100.Results All cases were surgically resected.Among GIST suffering sites, Stomach accounts for 63.9%(23/36),small intestine 30.6%( 11/36),colorectum 5.5%(2/36).15 cases are benign,3 are potential malignant and 18 are malignant.CD117 positive rate is 97%(35/36), 25% CD34 positive (9/36), 8.3% Actin positive (3/36) and 28% S-100 positive(1/36).Conclusion Positive CD117 marker is the most important diagnosis proof in final diagnosis of GIST and surgical treatment is still the main method for GIST therapy.