Relationship between cardiovascular disorders and thyroid function in non-dialysis patients with chronic renal failure

Objective: To investigate the changes of cardiovascular disorder and thyroid function, to explore the relationship in non-dialysis patients with chronic renal failure(CRF). Methods: A total of 70 cases in patients with CRF were enrolled in the retrospective study. The patients were divided into group A and group B by estimated glomerular filtration rate(MDRD)(eGFR) ≥30, 30 mL·min-1·(1.73 m2)-1. Clinical data, biochemical indicators and thyroid function were collected. Cardiac ultrasound measurement of cardiac lumen diameter parameters and function were assessed by echocardiography. The associations between the changes of cardiac structure and function with thyroid function were analyzed in different stages of eGFR. Results: In group B serum thyroid stimulating hormone(TSH), Left ventricular mass index were significantly higher than group A. The prevalence of high value in TSH was significant higher in group B(P=0.03). Linear regression analysis revealed that there was a negative correlation between eGFR measured by serum creatinine and cystatin C and left ventricular mass index(β=-0.32,P0.01). In the patients with left ventricular hypertrophy, a negative correlation between free triiodothyronine(FT3) and left ventricular mass index was observerd( β =-2.83,P 0.01). eGFR measured by serum creatinine and cystatin C was superior to eGFR measured by serum creatinine in assessing the cardiovascular disorder in different stages of kidney function, but inferior in assessing thyroid function in different stages of kidney function.Conclusions: Reduced kidney function associates with increased left ventricular mass index and higher TSH in non-dialysis patients with chronic renal failure. In the left ventricular hypertrophy patients of those, FT3 is negatively correlated to the left ventricular mass index。 The mechanism should be further researched.