EFFECTS OF CONJUGATED LINOLEIC ACID ON BLOOD LIPIDS AND PLASMA FATTY ACIDS IN AGED RATS

Objective: To study the effects of conjugated linoleic acid (CLA) on the composition of blood lipids and plasma fatty acids in aged rats. Method: SD aged rats were fed with high fat to induce atherosclerosis (AS) model, and then observe the effects of CLA on the contents of blood lipids and the composition of plasma fatty acids. Results: The contents of blood lipids and plasma fatty acids in the CLA-supplemented rats were changed, and the contents of triacylglycerols (TG) were decreased significantly. (1.15 mmol/L in the control vs 0.97, 0.91, 0.92 mmol/L in three CLA groups respectively). The contents of total saturated fatty acids decreased significantly, (46.15% in the control vs 42.33%, 41.34% and 39.07% in three CLA groups respectively). The contents of the total MUFA, CLA and n-6 PUFA increased in three CLA groups. Conclusion: CLA could improve blood lipids and the composition of plasma fatty acid in aged rats related to AS.