The relationship between ADAMTSs and knee osteoarthritis

Objective To observe and discuss the relationship between levels of ADAMTSs in synovial fluid and knee osteoarthritis in serum and the degree of pathological change.Methods Among 87 patients with single-side knee osteoarthritis,45 of them suffered from early-stage knee osteoarthritis,and 42 of them from medium-later-stage knee osteoarthritis.Examined levels of ADAMTSs in synovial fluid and serum.The control group was 30 healthy volunteers.Results Levels of ADAMTSs in synovial fluid and serum in these patients' bodies were higher than those of the control group.As the degree of pathological change becomes increasingly serious,such levels were increased significantly,and there was linear relationship between levels of ADAMTSs in synovial fluid and those in serum.Conclusion Levels of ADAMTSs in synovial fluid and serum in bodies of persons suffering from knee osteoarthritis are increased,and there is close relationship between the degrees of pathological change.Examination of levels of ADAMTSs in synovial fluid and serum facilitates diagnosis at early stage.