Antineoplastic effect of koumine in mice bearing H22 solid tumor

Objective To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice. Methods The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls. Results Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group. Conclusion Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.