Tu1981 Depletion of Endosome-Associated Protein SNX27 Inhibits Autophage in Human Colonic Cancer Cells

Endosome is a membrane-bounded compartment of the endocytic membrane transport pathway from the plasma membrane to the lysosome. Endosome-associated protein sorting nexin 27 (SNX27) is a unique member of sorting nexin family in possessing a PDZ domain. SNX27-retromer as a major retrieval and recycling hub for a variety of transmembrane proteins, many of which play crucial roles during organism growth and cellular homeostasis. We have previously shown that protein-protein interactions with the PDZ domain play roles