非酒精性脂肪肝
胰岛素抵抗
小檗碱
姜黄素
医学
青蒿
内科学
脂肪肝
发病机制
传统医学
脂联素
脂肪变性
药用植物
糖尿病
2型糖尿病
药理学
疾病
内分泌学
青蒿素
免疫学
恶性疟原虫
疟疾
作者
Jiao Xie,Ling Li,Lei Zhao
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2021-11-01
卷期号:21 (19): 3030-3036
被引量:2
标识
DOI:10.2174/1389557521666210405160658
摘要
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Its pathogenesis is closely related to insulin resistance, obesity, type 2 diabetes, and hyperlipidemia. Due to the complex pathogenesis, there are no specific medications for treating NAFLD. The most effective way to treat NAFLD is to lose weight through diet intervention and exercise, but a large number of in vitro and in vivo experiments have confirmed that a variety of natural drugs can interfere with NAFLD through many mechanisms, and the curative effect is remarkable. This paper reviews the action mechanism of crude extracts of medicinal plants (Polygonum multiflorum, Artemisia annua leaves, and Artemisia annua leaves) and natural products such as berberine (BBR), curcumin, betulinic acid (BA), ginsenoside Rg1 (G-rg1), and silybin on NAFLD, which aims to provide useful information for further research and development of new drugs to improve the cure rate of non-alcoholic fatty liver.
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