半胱氨酸蛋白酶
医学
神经科学
半胱氨酸蛋白酶1
生物信息学
药理学
作者
Anke Zhang,Zeyu Zhang,Yibo Liu,Cameron Lenahan,Houshi Xu,Junkun Jiang,Ling Yuan,Liangbo Wang,Yuanzhi Xu,Sheng Chen,Yuanjian Fang,Jianmin Zhang
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2021-11-11
卷期号:19
标识
DOI:10.2174/1570159x19666211111121146
摘要
: The caspase family is commonly involved in the pathophysiology of acute brain injury (ABI) through complex apoptotic, pyroptotic, and inflammatory pathways. Current translational strategies for caspase modulation in ABI primarily focus on caspase inhibitors. Because there are no caspase-inhibiting drugs approved for clinical use on the market, the development of caspase inhibitors remains an attractive challenge for researchers and clinicians. Therefore, we conducted the present review with the aim of providing a comprehensive introduction of caspases in ABI. In this review, we summarized the available evidence and potential mechanisms regarding the biological function of caspases. We also reviewed the therapeutic effects of caspase inhibitors on ABI and its subsequent complications. However, various important issues remain unclear, prompting further verification of the efficacy and safety regarding clinical application of caspase inhibitors. We believe that our work will be helpful to further understand the critical role of the caspase family, and will provide novel therapeutic potential for ABI treatment.
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