自闭症
双歧杆菌
失调
荟萃分析
肠道菌群
自闭症谱系障碍
心理学
医学
生物
免疫学
细菌
内科学
发展心理学
乳酸菌
遗传学
作者
Pedro Andreo-Martínez,María Rubio‐Aparicio,Julio Sánchez‐Meca,Alejandro Veas,Agustín Ernesto Martínez-González
标识
DOI:10.1007/s10803-021-05002-y
摘要
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD+ = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
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