Non-uniform attenuation correction using simultaneous transmission and emission converging tomography

Photon attenuation in cardiac single photon emission computed tomography (SPECT) is a major factor contributing to the quantitative inaccuracy and the decrease in sensitivity of lesion detection. A measured map of the attenuation distribution is used in combination with iterative reconstruction algorithms to accurately compensate for the variable attenuation in the chest. The transmission and emission data are acquired simultaneously using a multidetector, fan beam collimated SPECT system with a precisely aligned transmission line source (Tc-99m) at a different energy than the emission source (Tl-201). The contamination of transmission and emission data due to scatter and multiple photopeaks is removed based on measurements from the detectors acquiring only the emission data. The quantitative accuracy of cardiac SPECT is significantly improved using simultaneously acquired transmission and emission data which are obtained in clinically acceptable patient scanning times.>