化学
卤化物
酰化
烷基
催化作用
产量(工程)
电化学
镍
羧酸
有机化学
偶联反应
组合化学
电极
物理化学
冶金
材料科学
作者
Xiao Zhou,Lin Guo,Haoxiang Zhang,Raymond Yang Xia,Chao Yang,Wujiong Xia
标识
DOI:10.1002/adsc.202200003
摘要
Abstract A sustainable Ni‐catalyzed reductive acylation reaction of carboxylic acids via an electrochemical pathway is presented, affording a variety of ketones as major products. The reaction proceeds at ambient temperature using unactivated alkyl halides and N ‐hydroxyphthalimide (NHP) esters as coupling partners, which exhibits several synthetic advantages, including mild conditions and convenience of amplification (58% yield for 6 mmol scale reaction). magnified image
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