Prevalence and risk factors of antibodies to HLA according to different cut‐off values of mean fluorescence intensity in haploidentical allograft candidates: A prospective study of 3805 subjects

医学 人类白细胞抗原 抗体 免疫学 内科学 前瞻性队列研究 移植 风险因素 怀孕 血小板输注 造血干细胞移植 胃肠病学 血小板 抗原 生物 遗传学
作者
Nan Ma,Jiapei Guo,Xiang‐Yu Zhao,Lan‐Ping Xu,Xiao‐Hui Zhang,Yu Wang,Xiao‐Dong Mo,Yuanyuan Zhang,Yanrong Liu,Xiang‐Yu Zhao,Yifei Cheng,Kai‐Yan Liu,Xiao‐Jun Huang,Ying‐Jun Chang
出处
期刊:HLA: Immune Response Genetics [Wiley]
卷期号:100 (4): 312-324 被引量:8
标识
DOI:10.1111/tan.14704
摘要

The importance of anti-HLA antibodies in transplantation settings, such as HLA-mismatched or haploidentical hematopoietic stem cell transplantation and platelet refractoriness, is widely recognized. In previous reports, it was mentioned that several cut-off values of donor-specific anti-HLA antibodies mean fluorescence intensity (MFI) were related to graft rejection in the environment of HLA mismatched stem cell transplantation and the aim of this study was to investigate the prevalence and risk factors of anti-HLA antibodies according to those cut-off values of MFI. A total of 3805 patients with hematologic disease were prospectively enrolled and analyzed. When using MFI of anti-HLA antibodies ≥500, ≥1000, ≥1500, ≥2000, ≥5000, and ≥ 10,000 as cut-off values for positivity, the prevalence of class I or II anti-HLA antibodies ranged from 4.6% to 20.2% in all cases. When the MFI cut-off value was ≥500 for positivity, multivariate analysis indicated that platelet transfusion, underlying disease, and pregnancy were the most important risk factors for the presence of anti-HLA antibodies for the total patients. Subgroup analysis according to age, gender, and underlying disease showed that pregnancy was the most important risk factor for the presence of anti-HLA antibodies. For all patients (n = 3805), when anti-HLA antibody positivity was defined according to different MFI cut-off values, including ≥1000, ≥1500, ≥2000, ≥5000, and ≥ 10,000, an association of platelet transfusion and pregnancy with anti-HLA antibodies was also demonstrated. Our results suggest that pregnancy and platelet transfusion are the main risk factors for the prevalence of anti-HLA antibodies in haploid allograft candidates, providing evidence for guiding the evaluation of anti-HLA antibodies and helping donor selection for HLA-mismatched transplant candidates.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
happyness发布了新的文献求助20
2秒前
3秒前
4秒前
4秒前
SYLH应助林洁佳采纳,获得10
4秒前
5秒前
5秒前
壮观半鬼发布了新的文献求助10
6秒前
健壮的半青完成签到 ,获得积分10
6秒前
哎哟喂发布了新的文献求助10
7秒前
8秒前
荣安安完成签到,获得积分10
8秒前
9秒前
9秒前
可爱的函函应助wuyj采纳,获得10
9秒前
笨笨芯发布了新的文献求助10
10秒前
可yi发布了新的文献求助10
10秒前
牛油果发布了新的文献求助10
10秒前
DullElm发布了新的文献求助10
11秒前
13秒前
Yuxin发布了新的文献求助10
13秒前
嗯嗯嗯发布了新的文献求助10
13秒前
LM完成签到,获得积分10
13秒前
浪漫如云关注了科研通微信公众号
14秒前
鱼梓发布了新的文献求助10
15秒前
15秒前
17秒前
深情安青应助zzzz采纳,获得10
17秒前
xl关闭了xl文献求助
17秒前
wuyj完成签到,获得积分20
17秒前
独特的奇异果完成签到,获得积分10
18秒前
沉默傲芙发布了新的文献求助10
18秒前
Titter发布了新的文献求助10
19秒前
奶昔发布了新的文献求助10
20秒前
YJ888发布了新的文献求助10
21秒前
21秒前
21秒前
21秒前
西瓜完成签到,获得积分10
22秒前
高分求助中
Algorithmic Mathematics in Machine Learning 500
Handbook of Innovations in Political Psychology 400
Mapping the Stars: Celebrity, Metonymy, and the Networked Politics of Identity 400
Visceral obesity is associated with clinical and inflammatory features of asthma: A prospective cohort study 300
Getting Published in SSCI Journals: 200+ Questions and Answers for Absolute Beginners 300
Engineering the boosting of the magnetic Purcell factor with a composite structure based on nanodisk and ring resonators 240
HVAC 1 toolkit : a toolkit for primary HVAC system energy calculation 200
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3839677
求助须知:如何正确求助?哪些是违规求助? 3382042
关于积分的说明 10520950
捐赠科研通 3101446
什么是DOI,文献DOI怎么找? 1708092
邀请新用户注册赠送积分活动 822143
科研通“疑难数据库(出版商)”最低求助积分说明 773208