蛋氨酸腺苷转移酶
化学
蛋氨酸
酶
三磷酸腺苷
生物化学
氨基酸
作者
Chunzheng Li,Gang Gui,Li Zhang,Anqi X. Qin,Chen Zhou,Xiaoming Zha
标识
DOI:10.1021/acs.jmedchem.2c00395
摘要
Methionine adenosyltransferase 2A (MAT2A) is a rate-limiting enzyme in the methionine cycle that primarily catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine and adenosine triphosphate (ATP). MAT2A has been recognized as a therapeutic target for the treatment of cancers. Recently, a few MAT2A inhibitors have been reported, and three entered clinical trials to treat solid tumorsor lymphoma with MTAP loss. This review aims to summarize the current understanding of the roles of MAT2A in cancer and the discovery of MAT2A inhibitors. Furthermore, a perspective on the use of MAT2A inhibitors for the treatment of cancer is also discussed. We hope to provide guidance for future drug design and optimization via analysis of the binding modes of known MAT2A inhibitors.
科研通智能强力驱动
Strongly Powered by AbleSci AI