We fabricated a Peltier knife after a point-contact-structure Peltier device. The knife tip temperature reached -12.2°C at 16A. When direction of current, the tip was heated, and reached 174.7°C at 20A. Between 180°C and -20°C, the Peltier knife operation was changed from heating to cooling in 10s and from cooling to heating in 13s. The Peltier knife will be useful in medical treatment and bioelectronics.