Recent studies have shown that enamel matrix proteins may induce regeneration in periodontal intrabony defects. This paper presents preliminary results (6 to 12 months observation period) of the clinical application of enamel matrix protein (Emdogain) as an adjunct to periodontal surgical therapy of intrabony defects. The clinical results support reports that enamel matrix derivative may induce regeneration in intrabony defects, irrespective of the type of periodontal disease and/or type of intrabony defect involved.