医学
表皮生长因子受体
表皮生长因子受体抑制剂
受体
癌症
癌症研究
肿瘤科
生物信息学
内科学
生物
作者
Fortunato Ciardiello,Giampaolo Tortora
标识
DOI:10.1056/nejmra0707704
摘要
Functional activation of growth factors and receptors of the epidermal growth factor receptor (EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer treatment. This article discusses the mechanisms of action of EGFR inhibitors, their anticancer activity, and clinical issues concerning their use in the treatment of patients with cancer.
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