Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ‐Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles

Abstract The first direct and enantioselective vinylogous Michael/cyclization cascade reaction between acyclic β,γ‐unsaturated amides and isatylidene malononitriles has been developed. Optically active spirocyclic oxindoles have been obtained in good‐to‐excellent yields (84–96%) and enantioselectivity (79–97% ee ) in the presence of 2 mol% (DHQD) 2 PYR [2,5‐diphenyl‐4,6‐bis(9‐ O ‐dihydroquinyl)pyrimidine]. magnified image