等电点
介孔材料
吸附
扫描电子显微镜
透射电子显微镜
解吸
化学工程
傅里叶变换红外光谱
化学
肿胀 的
牛血清白蛋白
比表面积
核化学
材料科学
分析化学(期刊)
色谱法
有机化学
纳米技术
复合材料
工程类
催化作用
酶
作者
Thi Phuong Binh Nguyen,Jae‐Wook Lee,Wang Geun Shim,Hee Moon
标识
DOI:10.1016/j.micromeso.2007.06.054
摘要
SBA-15, mesoporous material, is a very excellent candidate for drug delivery system because its pore size is easy to control according to synthesis conditions and the presence of swelling agent. In this study, a known swelling agent, 1,3,5-trimethylbenzene (TMB), was used to increase the pore size with increased aging temperature and prolonged aging time. Furthermore, 3-aminopropyltriethoxysilane (APTES) was incorporated on SBA-15 surface via post synthesis method to separate protein effectively. The samples were characterized by X-ray diffraction (XRD), nitrogen adsorption and desorption analyses, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier Transform Infrared (FT-IR). Adsorption capacity increased with temperature at the isoelectric point (pI) of bovine serum albumin (BSA) regardless of the pore size of SBA-15 samples. Release studies were carried out in the range of pH from neutral to basic solution on unmodified and amine-modified samples. In addition, the adsorption mechanism was investigated by employing the pseudo-first order, pseudo-second order, and intraparticle diffusion models.
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