生物相容性材料
生物利用度
药物输送
药品
药理学
化学
医学
生化工程
传统医学
生物医学工程
有机化学
工程类
作者
Diogo Matias,Patrícia Rijo,Catarina Pinto Reis
标识
DOI:10.2174/0929867323666161028160855
摘要
Natural products have been frequently used as sources of clinical useful pharmaceuticals. However, some intrinsic characteristics of the natural drugs have limited their use, namely their solubility and chemical stability in physiologic mediums. Innovative drug delivery systems may help overcome such limitations, thus providing more effective administration of natural products. Phytosome (Indena SPA, Italy) is one of the most exciting recent delivery technologies that improves the oral bioavailability of the phytopharmaceuticals by their inclusion in equimolar complexes with dietary phospholipids with vesicular shape in aqueous environments. The purpose of this review is to characterize the state of the art of the phytosome as drug delivery system of natural products, including a discussion of the natural drug-phospholipid complex interactions, mechanisms of oral and topical delivery, methods of preparation and phytosome recent applications and patents in the 2006-2016 period. Keywords: Phytosome, phyto-phospholipidic complex, natural compounds, innovative drug delivery systems, preparation and characterization techniques, clinical and nutritional uses.
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