流行病学
医学
多发性硬化
入射(几何)
民族
长寿
全基因组关联研究
遗传流行病学
人口学
环境卫生
老年学
病理
遗传学
单核苷酸多态性
精神科
生物
基因型
人类学
物理
光学
社会学
基因
作者
Jonathan Howard,Stephen Trevick,David S. Younger
标识
DOI:10.1016/j.ncl.2016.06.016
摘要
The epidemiology of multiple sclerosis (MS) includes a consideration of genetic and environmental factors. Comparative studies of different populations have revealed prevalence and incidence rates that vary with geography and ethnicity. With a prevalence ranging from 2 per 100,000 in Japan to greater than 100 per 100,000 in Northern Europe and North America, the burden of MS is similarly unevenly influenced by longevity and comorbid disorders. Well-powered genome-wide association studies have investigated the genetic substrate of MS, providing insight into autoimmune mechanisms involved in the etiopathogenesis of MS and elucidating possible avenues of biological treatment.
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