医学
糖尿病
2型糖尿病
内科学
自身免疫性糖尿病
1型糖尿病
肥胖
人口
内分泌学
逻辑回归
全国健康与营养检查调查
环境卫生
作者
Josefin E. Löfvenborg,Tomas Andersson,Per Carlsson,Mozhgan Dorkhan,Leif Groop,Mats Martinell,Tiinamaija Tuomi,Alicja Wolk,Sofia Carlsson
出处
期刊:European journal of endocrinology
[Bioscientifica]
日期:2016-12-01
卷期号:175 (6): 605-614
被引量:40
摘要
Objective Sweetened beverage intake is associated with increased risk of type 2 diabetes, but its association with autoimmune diabetes is unclear. We aimed to investigate sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA); autoimmune diabetes with features of type 2 diabetes. Design/methods Data from a Swedish population-based study was used, including incident cases of LADA ( n = 357) and type 2 diabetes ( n = 1136) and randomly selected controls ( n = 1371). Diabetes classification was based on onset age (≥35), glutamic acid decarboxylase autoantibodies (GADA) and C-peptide. Sweetened beverage intake information was derived from a validated food frequency questionnaire. ORs adjusted for age, sex, family history of diabetes, education, lifestyle, diet, energy intake and BMI were estimated using logistic regression. Results Daily intake of >2 servings of sweetened beverages (consumed by 6% of participants) was associated with increased risk of LADA (OR: 1.99, 95% CI: 1.11–3.56), and for each 200 mL daily serving, OR was 1.15 (95% CI: 1.02–1.29). Findings were similar for sugar-sweetened (OR: 1.18, 95% CI: 1.00–1.39) and artificially sweetened beverages (OR: 1.12, 95% CI: 0.95–1.32). Similarly, each daily serving increment in total sweetened beverage conferred 20% higher type 2 diabetes risk (95% CI: 1.07–1.34). In type 2 diabetes patients, high consumers displayed higher HOMA-IR levels (4.5 vs 3.5, P = 0.0002), but lower HOMA-B levels (55 vs 70, P = 0.0378) than non-consumers. Similar tendencies were seen in LADA. Conclusions High intake of sweetened beverages was associated with increased risk of LADA. The observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance.
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