SR蛋白
RNA剪接
生物
蛋白质组
选择性拼接
RNA结合蛋白
转录组
翻译(生物学)
细胞生物学
基因
信使核糖核酸
遗传学
基因表达
拼接因子
核糖核酸
作者
Kundan Kumar,Shubham Kumar Sinha,Upasana Maity,Pulugurtha Bharadwaja Kirti,Koppolu Raja Rajesh Kumar
摘要
Abstract Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and plants. SR proteins are involved in constitutive and alternative splicing, thereby regulating the transcriptome and proteome diversity in the organism. In addition to their role in splicing, SR proteins are also involved in mRNA export, nonsense‐mediated mRNA decay, mRNA stability, and translation. Due to their pivotal roles in mRNA metabolism, SR proteins play essential roles in normal growth and development. Hence, any misregulation of this set of proteins causes developmental defects in both plants and animals. SR proteins from the animal kingdom are extensively studied for their canonical and noncanonical functions. Compared with the animal kingdom, plant genomes harbor more SR protein‐encoding genes and greater diversity of SR proteins, which are probably evolved for plant‐specific functions. Evidence from both plants and animals confirms the essential role of SR proteins as regulators of gene expression influencing cellular processes, developmental stages, and disease conditions. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing
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