Discovery of copper(II) complexes with plumbagin and bipyridine as chemodynamic therapy agents with enhanced antitumor activity by targeting mitochondria

Four copper(II) complexes with plumbagin and bipyridine (Cu1–Cu4) were synthesized as chemodynamic therapy agents with enhanced antitumor activity. As lipophilic and positively charged compounds, Cu1–Cu4 were preferentially accumulated in mitochondria...