Synthesis and investigation of antimicrobial activity of SrWO4 nanoparticles against a panel of Gram-positive and Gram-negative bacteria

Abstract Introduction: Elevated resistance of bacteria to common antibiotics and the lack of efficient alternatives to treat bacterial infections are the main concerns of health services. Therefore, the need to figure out new therapeutic options is inevitable. Strontium Tungsten Oxide nanoparticles (SrWO 4 NPs) as an antimicrobial agent have recently received attention. However, few reports have been published on its antimicrobial properties. Material and methods: In the present study, SrWO 4 NPs were synthesized by hydrothermal method. To confirm the NPs synthesis procedure, spherical morphology, and particle size, XRD, SEM, TEM, FT-IR, and EDS analysis were performed. The antimicrobial properties of SrWO 4 NPs were assessed via the micro broth dilution method. Results: The NPs size was nearly distributed 21 to 27 nm. The antibacterial effects of SrWO 4 NPs against both Gram-positive ( Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 29212) and Gram-negative bacteria ( Pseudomonas aeruginosa (PAO1), Escherichia coli (ATCC 25922), and Enterobacter aerogenes (ATCC 13048) were evaluated using the micro broth dilution assay. The lowest and highest minimum inhibitory concentrations (MIC) were observed against Enterococcus faecalis (16 µg/mL) and Pseudomonas aeruginosa (256 µg/mL), respectively. Conclusions: The chemical method can be used with high efficiency to synthesize NPs. Additionally; SrWO 4 NPs could serve as a valuable antibacterial candidate, particularly against Gram-positive bacteria.