Peptide‐Induced Hydrogelation with Ordered Metal‐Organic Framework Nanoparticles Generating Reactive Oxygen Species for Integrated Wound Repair

Abstract Hydrogels, with their high water content and flexible nature, are a promising class of medical dressings for combating bacterial wound infections. However, their development has been hindered by low sterilization efficiency. Here, this issue is addressed by designing a peptide hydrogel that assembles ordered metal‐organic framework (MOF) nanoparticles with photocatalytic bactericidal activity. Specifically, a short peptide, Nap‐Gly‐Phe‐Phe‐His (Nap‐GFFH), is used to induce the assembly of zinc‐imidazolate MOF (ZIF‐8) into a hydrogel (NHZ gel). This innovative structure integrates three key features: 1) ZIF‐8 nanoparticles are encapsulated within the hydrogel, overcoming their inherent brittleness, insolubility, and limited moldability; 2) the ordered ZIF‐8 structure enhances charge transfer, enabling efficient generation of reactive oxygen species (ROS); and 3) ZIF‐8 simultaneously improves the photocatalytic bactericidal efficiency and mechanical properties of the hydrogel. The NHZ gel demonstrates remarkable antibacterial performance, achieving >99.9% and 99.99% inactivation of Escherichia coli and Staphylococcus aureus , respectively, within 15 min of simulated solar radiation. Additionally, the NHZ gel exhibits excellent biocompatibility, water retention, and exudate absorption, highlighting its broad potential for wound healing.