人参
医学
荟萃分析
严格标准化平均差
置信区间
内科学
不利影响
子群分析
随机对照试验
相对风险
物理疗法
传统医学
替代医学
病理
作者
Xiaotong Li,Mingxiao Yang,Yi Lily Zhang,Yen-Nien Hou,Colleen M. Smith,Deborah Korenstein,Jun J. Mao
出处
期刊:Journal of integrative and complementary medicine
[Mary Ann Liebert]
日期:2023-08-01
卷期号:29 (8): 468-482
被引量:1
标识
DOI:10.1089/jicm.2022.0532
摘要
Objectives: Ginseng has been widely used in fatigue management. However, its efficacy on fatigue remains unclear. This study aimed to assess the efficacy and safety of ginseng and ginseng herbal formulas for fatigue in randomized clinical trials (RCTs). Methods: The authors searched PubMed, Embase, Cochrane, Web of Science, and Allied and Complementary Medicine Database (AMED) databases from inception to July 6, 2022. Outcomes included fatigue severity, quality of life (QoL), and adverse events (AEs). Quality of evidence was assessed using the Cochrane Risk of Bias Tool. They pooled all included data and performed subgroup analysis by fatigue type, assessment instrument, and ginseng type. Results: The authors included 19 RCTs. Pooled analyses found no significant reduction in fatigue severity with ginseng versus controls (standardized mean difference [SMD]: −0.36, 95% confidence interval [CI]: −0.82 to 0.11, p = 0.13). In subgroup analysis, there was significant fatigue reduction with the ginseng herbal formula (SMD: −0.39, 95% CI: −0.66 to −0.13, p = 0.004) and chronic fatigue (CF) (SMD: −0.30, 95% CI: −0.56 to −0.03, p = 0.03) compared to controls. Ginseng produced significant reductions in general (i.e., non-disease-specific) fatigue compared to controls (SMD: −0.48, 95% CI: −0.71 to −0.25, p < 0.0001). Ginseng was associated with a trend toward QoL improvement (p = 0.05) and did not increase AEs compared with controls. Effect sizes were small. Conclusion: Ginseng herbal formulas improved fatigue severity compared to controls, especially among patients with CF, but with a small effect size. Rigorous RCTs as well as guidelines for standard ginseng usage are needed to further evaluate the effects of ginseng for fatigue and ensure proper use.
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