This paper aims to assess the economic burden of low back pain (LBP) in the United States through a comprehensive cost-of-illness analysis. The study examines direct medical costs, indirect costs, and intangible costs associated with LBP, providing valuable insights into the economic impact of this condition. By analyzing direct medical costs, the study assesses the expenses related to healthcare services such as physician visits, diagnostic tests, medications, and surgical procedures. These costs contribute to the overall economic burden of LBP by encompassing the resources utilized for the treatment and management of the condition. In addition to direct medical costs, the analysis also considers indirect costs associated with LBP.