医学
白细胞减少症
噬血作用
泼尼松龙
贫血
淋巴细胞增多症
髓外造血
病理
胃肠病学
脾切除术
免疫学
噬血细胞性淋巴组织细胞增多症
骨髓
内科学
脾脏
全血细胞减少症
化疗
造血
疾病
生物
遗传学
干细胞
作者
Michihito Tagawa,Minori Aoki,Akiko Uemura,Masashi Yanagawa,Takayuki Mineshige,Ken-Ichi Watanabe,Yoshiyasu Kobayashi
摘要
A 10-year-old spayed female domestic short-haired cat presented with depression, anorexia, and tachypnea. A complete blood count revealed moderate regenerative anemia, severe leukopenia, and mild thrombocytopenia. Antibodies against feline immunodeficiency virus (FIV) were also detected. Abdominal radiography and ultrasonography revealed severe splenomegaly. Cytologic evaluation of the spleen revealed macrophagic infiltration with hemophagocytosis. Bone marrow aspiration revealed erythroid hyperplasia with no other abnormalities. A presumptive diagnosis of hemophagocytic syndrome secondary to immune-mediated hemolytic anemia was made based on a positive direct Coombs test result. Blood transfusion, prednisolone, and immunosuppressive treatments were performed; however, the blood abnormalities did not improve. The cat was then administered prednisolone and chlorambucil, followed by splenectomy. Leukopenia immediately recovered, and packed cell volume increased slightly. However, the blood abnormalities recurred, and the cat died. To the best of our knowledge, this is the first report of hemophagocytic syndrome secondary to immune-mediated disease in an FIV-positive cat.
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