平衡
癌症
免疫系统
钙代谢
癌细胞
钙
癌症治疗
细胞生物学
功能(生物学)
化学
生物
医学
免疫学
内科学
作者
Feng Yu,Jianlin Wang,Ji-Min Cao,Fangfang Cao,Xiaoyuan Chen
出处
期刊:Exploration
[Wiley]
日期:2023-10-10
卷期号:4 (1)
被引量:1
摘要
Abstract Calcium ions (Ca 2+ ) are indispensable and versatile metal ions that play a pivotal role in regulating cell metabolism, encompassing cell survival, proliferation, migration, and gene expression. Aberrant Ca 2+ levels are frequently linked to cell dysfunction and a variety of pathological conditions. Therefore, it is essential to maintain Ca 2+ homeostasis to coordinate body function. Disrupting the balance of Ca 2+ levels has emerged as a potential therapeutic strategy for various diseases, and there has been extensive research on integrating this approach into nanoplatforms. In this review, the current nanoplatforms that regulate Ca 2+ homeostasis for cancer therapy are first discussed, including both direct and indirect approaches to manage Ca 2+ overload or inhibit Ca 2+ signalling. Then, the applications of these nanoplatforms in targeting different cells to regulate their Ca 2+ homeostasis for achieving therapeutic effects in cancer treatment are systematically introduced, including tumour cells and immune cells. Finally, perspectives on the further development of nanoplatforms for regulating Ca 2+ homeostasis, identifying scientific limitations and future directions for exploitation are offered.
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