Secretion is a fundamental process in which cells release substances to their external environments. Secretion is essential for many body functions, including growth, digestion, and cell communication. To be secreted, proteins must pass through various stations inside cells, which together form what is called the secretory pathway. In this article, I will tell you about the secretory pathway and the stages that proteins go through from their production up until their secretion. Then, I will present the original work that we did in our lab to identify genes related to the secretory pathway in yeast cells. Finally, I will explain the importance of our work to the overall study of the secretory pathway, both in yeast and mammalian cells.