青光眼
眼压
微珠(研究)
高眼压
眼科
视网膜神经节细胞
医学
体内
视网膜
生物
生物化学
生物技术
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 71-76
被引量:1
标识
DOI:10.1007/978-1-0716-3409-7_8
摘要
Glaucoma is an irreversible blinding disease characterized by the loss of retinal ganglion cells. Development of therapeutics relies on suitable models and, given its complex nature, these are typically in vivo models. A widely used model, owing to its relative simplicity, is the microbead model. This model involves the injections of beads into the anterior chamber, which are suitably sized to block the aqueous outflow pathway, leading to an elevation in intraocular pressure and ultimately, retinal ganglion cell death. In this chapter, we describe in detail the materials and methods for modelling glaucoma using microbeads (both magnetic and nonmagnetic).
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