[Effects of macrophage glycolytic reprogramming on tuberculosis granuloma formation].

The formation of granulomatous lesions is a typical pathological feature of tuberculosis, and infection with Mycobacterium tuberculosis is the main cause. Although the mechanism underlying granuloma formation remains unclear, increasing evidence suggests that immune metabolism plays an important role. In this review, we summarized the latest advances in macrophage glycolytic reprogramming in tuberculosis granuloma formation to discover new methods for early diagnosis and provided new ideas for tuberculosis therapeutics based on the regulation of immune metabolism.结核病的典型病理特征为肉芽肿形成，结核分枝杆菌感染是其主要病因。目前肉芽肿形成的机制尚不完全清楚，研究显示免疫代谢机制在其中发挥了重要作用。本文从巨噬细胞葡萄糖代谢重编程角度总结近年来结核肉芽肿形成机制的研究进展，以期寻找早期诊断新方法，并为发展基于免疫代谢调控的药物治疗提供新思路。.