DABCO-promoted reaction sequence of β-nitro alcohols and α-oxoaldehydes: construction of diverse tetrahydrofurans and total synthesis of (+)-bruguierol B

A DABCO-promoted highly efficient reaction sequence has been developed, where β-nitro alcohols reacted smoothly with α-oxoaldehydes to afford diverse tetrahydrofuran derivatives. This strategy enabled the first total synthesis of (+)-bruguierol B.