Molecular Etiology and Clinical Significance of Discordant Human Papillomavirus Testing in p16+ Oropharyngeal Cancers

HPV RNAScope appears unlikely to detect HPV status misclassification or be prognostic in typical p16+ OPCs treated surgically in the United States. Confirmatory RNAScope can produce misleading false negatives in this population through various mechanisms and should be used selectively rather than routinely.