Imaging Mass Cytometry Immune Profiling of Hunner Lesions in a Convenience Sample of Patients With Interstitial Cystitis/Bladder Pain Syndrome

Here, we demonstrate the use of highly multiplexed imaging in combination with novel analysis pipelines as a feasible method to understand the spatial organization of HLs. This pilot study suggests that these methods will be useful to prospectively characterize and evaluate the local immune microenvironment in HL-IC/BPS and could uncover mechanisms of disease pathogenesis.