Anti-inflammatory and Antioxidant Activities of Root Extract of Morinda officinalis from Quang Binh Province, Vietnam

In Asia, Morinda officinalis F.C. How, a member of the Rubiaceae family, is frequently used as a medicinal plant and is thought to have several biological properties. This study aimed to evaluate the anti-inflammatory and antioxidant of M. officinalis. Nitric oxide (NO) generation in RAW 264.7 macrophage cells was used to measure the anti-inflammatory effects, while the antioxidant activity of the extract was determined using the 2,2'-azinobis (3- ethylbenzothiazoline-6-sulfonate (ABTS) assay. The results show that the root extract of the plant dramatically reduced the amount of NO produced, with IC50 values of 37.11 ± 2.6 µgmL−1 (compared to IC50 14.20 ±1.1 µgmL−1 for dexamethasone). The antioxidant activity against ABTS has an SC50 value of 318.37 ± 12.21 µgmL−1 (Trolox, IC50 7.02 ± 0.24 µgmL−1). These results gave important background data for future research on the anti-inflammatory and antioxidant benefits of M. officinalis.