美波利祖马布
医学
哮喘
嗜酸性
单克隆抗体
嗜酸性粒细胞
生物标志物
免疫学
白细胞介素5
内科学
抗体
白细胞介素
病理
细胞因子
生物化学
化学
作者
Claudio Candia,Pasquale Ambrosino,Silvestro Ennio D’Anna,Andréa Motta,Mauro Maniscalco
出处
期刊:Biomarkers in Medicine
[Future Medicine]
日期:2024-04-16
标识
DOI:10.2217/bmm-2023-0801
摘要
Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62Llow inflammatory eosinophils (iEos) and identified an intriguing correlation between such iEos and asthma control scores. Moreover, CD62Llow iEos were reduced after treatment with the anti-IL-5 monoclonal antibody mepolizumab. In the future, we believe that eosinophil subtypes could represent a useful biomarker in severe eosinophilic asthma, helping clinicians characterize patient endotypes and monitoring the response to biological drugs.
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