代谢工程
合成生物学
生化工程
商业化
原材料
可持续生产
生产(经济)
可再生资源
生物塑料
生物燃料
生物技术
可再生能源
化学
工程类
生物
有机化学
业务
废物管理
生态学
计算生物学
宏观经济学
经济
酶
营销
作者
S. Gu,Fang Zhu,Lin Zhang,Jianping Wen
标识
DOI:10.1021/acs.jafc.4c00002
摘要
Mid-to-long-chain dicarboxylic acids (DCAi, i ≥ 6) are organic compounds in which two carboxylic acid functional groups are present at the terminal position of the carbon chain. These acids find important applications as structural components and intermediates across various industrial sectors, including organic compound synthesis, food production, pharmaceutical development, and agricultural manufacturing. However, conventional petroleum-based DCA production methods cause environmental pollution, making sustainable development challenging. Hence, the demand for eco-friendly processes and renewable raw materials for DCA production is rising. Owing to advances in systems metabolic engineering, new tools from systems biology, synthetic biology, and evolutionary engineering can now be used for the sustainable production of energy-dense biofuels. Here, we explore systems metabolic engineering strategies for DCA synthesis in various chassis via the conversion of different raw materials into mid-to-long-chain DCAs. Subsequently, we discuss the future challenges in this field and propose synthetic biology approaches for the efficient production and successful commercialization of these acids.
科研通智能强力驱动
Strongly Powered by AbleSci AI