化学
生物分子
拉曼光谱
化学生物学
分子
化学成像
化学种类
系统生物学
纳米技术
生物物理学
分析化学(期刊)
计算生物学
生物化学
计算机科学
环境化学
人工智能
光学
物理
生物
高光谱成像
有机化学
材料科学
作者
Kosuke Dodo,Katsumasa Fujita,Mikiko Sodeoka
摘要
In chemical biology research, various fluorescent probes have been developed and used to visualize target proteins or molecules in living cells and tissues, yet there are limitations to this technology, such as the limited number of colors that can be detected simultaneously. Recently, Raman spectroscopy has been applied in chemical biology to overcome such limitations. Raman spectroscopy detects the molecular vibrations reflecting the structures and chemical conditions of molecules in a sample and was originally used to directly visualize the chemical responses of endogenous molecules. However, our initial research to develop "Raman tags" opens a new avenue for the application of Raman spectroscopy in chemical biology. In this Perspective, we first introduce the label-free Raman imaging of biomolecules, illustrating the biological applications of Raman spectroscopy. Next, we highlight the application of Raman imaging of small molecules using Raman tags for chemical biology research. Finally, we discuss the development and potential of Raman probes, which represent the next-generation probes in chemical biology.
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